RECOGNIZING, DIAGNOSING, AND TREATING TRANSTHYRETIN AMYLOID CARDIOMYOPATHY (ATTR-CM): TARGETING CONTINUING MEDICAL EDUCATION (CME) TO THOSE WHO AREN’T TREATING ATTR-CM

Ophtalmologic changes in transthyretin familial amyloid polyneuropathy (ATTR-FAP)

Background Familial amyloid polyneuropathy (FAP) is an inherited disorder with autosomal dominant transmission and multiple phenotypes, characterized by systemic accumulation of amyloid fibrils. The most common type of FAP is related to a mutant transthyretin (TTR). TTR is mainly synthesized in the liver, but few amount of TTR is produced in the eye, namely in retinal pigment epithelium, which ...

Imaging cardiac ATTR amyloid

The heart is the principal site of involvement in nonhereditary ATTR amyloidosis and a major driver of treatment options and prognosis in hereditary forms of the disease. The goals of cardiac imaging in amyloidosis are to aid diagnosis, provide prognostic information, track disease progression and evaluate response to therapy. Echocardiography has long been the mainstay of cardiac evaluation in...

Continuing medical education (CME): goals and objectives.

Transthyretin-Derived (ATTR) Amyloidotic Cardiomyopathy After Receiving a Domino Liver Allograft.

Pressure-volume relationships in patients with transthyretin (ATTR) cardiac amyloidosis secondary to V122I mutations and wild-type transthyretin: Transthyretin Cardiac Amyloid Study (TRACS).

BACKGROUND ATTR cardiac amyloidosis can result from a mutated variant of transthyretin (eg, V122I) or wild-type variant (ATTRwt). We evaluated pressure-volume (PV) indices at baseline and over time to further characterize abnormal pump function in these subjects. METHODS AND RESULTS Twenty-nine subjects (18 with ATTRwt and 11 with ATTRm (V122I) had 2-dimensional echocardiograms with complete ...